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From the Editor…

Posted in Editor's introduction on 10th Dec 2012

Martin Turner and Gwenaëlle Douaud provide us with a stimulating account on recent thoughts about MND and how the loss of inhibitory interneurons may underlie some aspects of the disease.They discuss all this in the context of some of the known associations between MND and athleticism and this review certainly gets you thinking about neurodegenerative conditions in a completely new way.

The concept of involuntary musical imagery and a spectrum of musical symptoms is introduced to us by Lassi Liikkanen from Finland. It appears to be prevalent in that it occurs at least once a week in 90% of Finnish internet users who filled out an online questionnaire (presumably not during the Olympic closing ceremony).This imagery is not just about sticky tunes or unshakeable earworms,but can include palinacousis:‘the auditory illusion of persistence of sound impressions after cessation, sometimes music’, and musical obsessions.

Stephen Price and colleagues in the article for the Neurosurgical series, take us through the diagnosis and treatment of high grade gliomas – tumours that carry with them a dire prognosis.They explain how better defining molecular markers expressed within tumours has helped to better predict their behaviour and responsiveness to therapy. This excellent up-to-date account also looks to the future and agents that may prove useful in the clinic including a range of targeted therapies, some of which will hopefully be approved for use both in Europe and the US!

Alys Mikolajczyk and Andrew Bateman in the article for the Rehabilitation Section of ACNR discuss some of the more subtle, but clinically relevant, consequences of stroke in terms of emotional and affective problems.They discuss how common these problems are and how they can be approached through psychodynamic counselling by taking us through a study they conducted in 15 patients.

Ray Chaudhuri in a Brittania sponsored article discusses the use of apomorphine and DuoDopa® in patients with advanced Parkinson’s disease and how these two therapies match up in terms of helping all aspects of the disorder, not just the motor features of these conditions.

Finally, Suffolk artist Jane Southgate weaves together neuronal strands in her art that she describes in her short article.

We have a large collection of conference reviews in this issue and our usual journal and book reviews, and as usual we hope you enjoy this issue of ACNR.

Roger Barker,  Co-Editor

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