Karen P Steel

Edward Roberts, Adolfo Bronstein, Barry M Seemungal

Florence R Fricker and David Bennett

It is forty years since the first full report of long-term potentiation (LTP), a presumed cellular substrate for learning and memory. This review will provide an update on some recent advances in our understanding of the mechanisms underlying hippocampal LTP and address their potential clinical relevance. Introduction The hippocampus plays a fundamental role in learning […]

The last two decades have witnessed a rapid increase in the number of inherited disorders caused by ion channel mutations. One of the major challenges is to delineate the full clinical spectrum of these ‘channelopathies’. Among this expanding group, neurological ion channel disorders are among the best characterised, reflecting the fundamental importance of electrical excitability […]