5th Rome Debate on Developmental and Epileptic Encephalopathies

Event Notes:

By bringing together neurologists, epileptologists, geneticists, neonatologists, neuroscientists, and allied health professionals, the meeting fosters a platform for debate, knowledge exchange, and envisioning future directions in early diagnosis and intervention. The ultimate goal is to advance strategies that can meaningfully improve developmental outcomes for infants affected by TSC.

This year’s edition will bring together internationally recognized experts to explore the most recent advances in the physiopathology, early diagnosis, and treatment of TSC-associated DEE. Through a series of focused presentations and live discussions, we will examine the roles of mTOR dysregulation, interneuronopathy, metabolic pathways, and gene variants in shaping disease trajectories, and we will address cutting-edge therapeutic strategies—from precision medicine to prenatal and early postnatal interventions, up to future gene-editing approaches.

The meeting offers an exceptional opportunity to exchange ideas with leaders in the field, discuss open challenges, and contribute to shaping the evolving landscape of early intervention in TSC.

Participation is free of charge, but registration is compulsory.

We warmly encourage clinicians, researchers, trainees, and all professionals involved in epilepsy, TSC, and neurodevelopmental disorders to join us for this important scientific dialogue.