19 December, 2024: A study led by Mark Nelson, PhD, from the Larner College of Medicine at the University of Vermont, has identified a new mechanism, Electro-Calcium (E-Ca) Coupling, that integrates electrical and calcium signalling to regulate blood flow in the brain. Published in PNAS, the research redefines how capillaries ensure precise oxygen and nutrient…
Category: Research
Unlocking the blood-brain barrier?
Researchers at the Icahn School of Medicine at Mount Sinai have developed an innovative approach—demonstrated in mouse models and isolated human brain tissue—to safely and effectively deliver therapeutics into the brain, providing new possibilities for treating a wide range of neurological and psychiatric diseases. 29 November 2024: Published in the November 25 online issue of Nature Biotechnology [https://doi.org/10.1038/s41587-024-02487-7],…
Fast track approval in Fabry disease?
Sangamo Therapeutics announces alignment with FDA on Accelerated Approval Pathway for ST-920 in Fabry Disease: BLA submission expected in 2025 – U.S. Food and Drug Administration (FDA) provides a clear regulatory pathway to Accelerated Approval for isaralgagene civaparvovec using data from ongoing Phase 1/2 STAAR study, avoiding requirement for additional registrational study and accelerating estimated time…
Human-specific genes linked to brain development and disorders
Link discovered between two human-specific genes and the SYNGAP1 gene, which is associated with intellectual disability and autism spectrum disorders 14th October 2024: A team of researchers led by Prof. Pierre Vanderhaeghen (VIB-KU Leuven), in collaboration with scientists from Columbia University and Ecole Normale Supérieure, has discovered a link between two human-specific genes, SRGAP2B and…
Study reveals high neurodegenerative risk among former international rugby players
A study led by the University of Glasgow has revealed the first major insights into lifelong health outcomes in former international rugby union players. In findings published in the Journal of Neurology, Neurosurgery and Psychiatry, the researchers found that former international rugby players had an approximately two and a half times higher risk of neurodegenerative…
Ratlas: A new rat brain atlas set to revolutionise neuroscience
The BNA has announced the launch of Ratlas, a new – and freely available – resource that will increase the accuracy and efficiency of experiments and also help to reduce animal numbers used for neuroscience research across the UK. Ratlas is an atlas of the rat brain that has been developed to revolutionise and support vital…
