Switching to second line MS DMTs associated with decreased relapse rate

People with multiple sclerosis (MS) who switch between more than two disease-modifying therapies (DMTs) have a higher risk of relapses compared with those who never switch, regardless of how well these patients adhere to their prescribed medications, according to real-world study in Canada.

According to the researchers, these findings are consistent with a greater number of treatment switches in individuals with a poor response to different therapies and/or higher disease activity.

However, among patients who ever switched treatments, those who changed to second-line DMTs had a 56% lower risk of relapse after the switch compared with those who remained on a first-line DMT. That result suggests that higher-efficacy therapies can more effectively control relapses in these patients.

Front. Neurol., 06 September 2023. Volume 14 – 2023 | https://doi.org/10.3389/fneur.2023.1243589

This provides a strong rationale for escalating therapy among those who have relapses requiring intervention